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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: June 2024

Volume 9 | Issue 6

Impact factor: 8.15

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Paper Title: FORMULATIONS AND EVALUATION OF NISOLDIPINE SUSTAINED RELEASE MATRIX TABLETS
Authors Name: Gangavarapu Nadia Psalms , Dr SRINIVASRAO MANDE , LALITHA REPUDI , Dr KUMARASWAMY GANDLA , Sravanthi Gandu
Unique Id: IJSDR2405021
Published In: Volume 9 Issue 5, May-2024
Abstract: The Present study was undertaken with an aim to formulate and evaluate Nisoldipine sustained release matrix tablets, a centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. Preformulation studies were carried and results were found to be satisfactory. The compatible excipients were selected for the formulation development.Experiment was performed by using both dry and wet granulation techniques based on the flow properties of API. In order to increase the flow property of the tablets, wet granulation was chosen for further formulation and found to be satisfactory. During development of formula, in-process tests such as bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose were evaluated for granules and hardness, friability, weight variation, thickness and disintegration were evaluated for the core tablets. Core tablets were coated with coating suspension.Finished products were evaluated for hardness, friability, weight variation, thickness, disintegration, dissolution and drug content.The developed trials were tested for in-vitro dissolution profile and compared with the reference product Carisoma. Stability studies performed at 45°C /75% RH, 25oC /60% RH for 2 months. Stability samples were evaluated initially and after 2 months. The results were compared with the pre-determined specifications. All the results were found to be satisfactory.
Keywords: : Nisoldipine; sustained release matrix tablets; Stability studies; formulate and evaluate
Cite Article: "FORMULATIONS AND EVALUATION OF NISOLDIPINE SUSTAINED RELEASE MATRIX TABLETS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 5, page no.151 - 172, May-2024, Available :http://www.ijsdr.org/papers/IJSDR2405021.pdf
Downloads: 000342234
Publication Details: Published Paper ID: IJSDR2405021
Registration ID:211208
Published In: Volume 9 Issue 5, May-2024
DOI (Digital Object Identifier):
Page No: 151 - 172
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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