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Issue: June 2024

Volume 9 | Issue 6

Impact factor: 8.15

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Paper Title: Development and Evaluation of Psidium guajava Loaded Herbal Nail Lacquer for the Treatment of Onychomycosis Fungal Infection
Authors Name: Navneet Mehan , Ritika Chauhan , Manit Singh , Himanshu Sharma , Suman Anjali, Lalit Sharma
Unique Id: IJSDR2405028
Published In: Volume 9 Issue 5, May-2024
Abstract: ABSTRACT A well-known nail fungus known by the names Dermatophytes onychomycosis and Tineaunguium is onychomycosis. The pathogens that cause onychomycosis are dermatophytes, Candida, and non-dermatophytic molds. This study has produced a natural nail lacquer that is antifungal. The objective of this study was to reduce the course of treatment and deliver a consistent release of Psidium guajava over an extended period of time—up to 24 hours. It was anticipated that this would increase patient cooperation as well as potency. The nail lacquer preparation was created through straightforward mixing and its non-volatile content was examined. Functional group identification, drug content estimation, gloss, viscosity, drying time, drug diffusion investigations, and anti-fungal studies are among the applications for FTIR analysis. The nail lacquer with the best non-volatile content, drug release, drug content estimation, and zone of inhibition was made up of 4% Psidium guajava, 8% Eudragit RL-100, 2% ethyl cellulose, 2% ethyl acetate, 0.8% Dibutylphthalate, 10% salicylic acid, and 0.4% acetone out of all the formulations. It is possible that the medication release continued for up to 24 hours, and 72.25% of the drug was delivered overall. Phenols and flavonoids were detected in the acetone extract of the Psidium guajava-loaded nail lacquer, according to FTIR analysis. An expedited stability assessment of the specially developed formulation F4 was carried out for one month at 42 ± 2 °C in accordance with ICH rules, revealing that no significant alteration in the original features was observed. Thus, it follows that antifungal nail lacquer is among the ground-breaking drugs that could revolutionize the pharmaceutical and medical fields.
Keywords: Keywords: Psidium guajava, Nail lacquer, Onychomycosis, fungus, Tineaunguium.
Cite Article: "Development and Evaluation of Psidium guajava Loaded Herbal Nail Lacquer for the Treatment of Onychomycosis Fungal Infection", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 5, page no.212 - 221, May-2024, Available :http://www.ijsdr.org/papers/IJSDR2405028.pdf
Downloads: 000342234
Publication Details: Published Paper ID: IJSDR2405028
Registration ID:211251
Published In: Volume 9 Issue 5, May-2024
DOI (Digital Object Identifier):
Page No: 212 - 221
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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